Dec 12, 2024  
2015-2016 University Catalog 
    
2015-2016 University Catalog [ARCHIVED CATALOG]

Integrated Biomedical Sciences


Integrated Biomedical Sciences: Admission Requirements


Applicants must enter the program in the fall semester in order to begin the required coursework in the core curriculum. The deadline for submission of applications is generally March 1. International applications can be accepted after March 1 but must take into consideration the delays associated with the necessary visa arrangements. The Integrated Biomedical Sciences Program has the following requirements for admission to its program:

  • A baccalaureate degree from an accredited college
  • Coursework in biology, cellular biology, molecular biology, physics, chemistry, organic chemistry, physical chemistry and mathematics, including calculus, is highly recommended. Upper-level biochemistry or physiology courses are also highly recommended.
  • Academic transcripts from all baccalaureate and post-baccalaureate educational experiences are required. These should provide a minimal grade point average of 3.0 overall (A = 4.0). Higher grades are expected in science courses and evidence of research experience is preferred.
  • GRE or MCAT scores are required. All applicants whose native language is not English are required to take the Test of English as a Foreign Language (TOEFL). Applicants from foreign countries must have their transcripts evaluated by an independent agency (i.e., ECE and WES).
  • A statement of the applicant’s interests and goals needs to be included as an essay in their application, if possible Identify a particular area of interest.
  • Three letters of recommendation preferably from science faculty who can evaluate the character of the applicant, their academic and research performance, and their ability to think and work independently.

The Admissions Committee will evaluate applications. All prior academic experience and the letters of recommendation will be evaluated for an indication of the applicant’s potential for success as a graduate student and future independent investigator. With rare exceptions, PhD applicants will be required to interview with faculty members before admission to the program. Acceptance into the doctoral program is limited by the availability of faculty and also by the availability of stipends. All accepted doctoral students receive a competitive stipend and tuition scholarship. The stipend and tuition scholarship is renewed each year providing the student is making satisfactory progress towards the degree.

Integrated Biomedical Sciences: Curriculum


Year 1


Year 2:


Note:


GCC = Graduate Core Curriculum
*GCC XXX Actual courses numbers will vary with elective or cognate required by the track.
BTN = Biotechnology course

In Years 3-5 the emphasis is on research. The student works with their track director, dissertation advisor and their committee to determine the most appropriate mix of electives and research hours. A typical registration is listed below:

  • GCC - XXX Electives 9 credit hours total to be dispersed from the 2nd through 4th year
  • GCC - XXX Cognates (track specific requirements) 8 hr from 2nd through 4th year
  • GCC - 694-698 Advanced Topics (1) 1 semester hour each Fall and Spring term 2nd through 4th year. The topic course should align with your track or research interests.
  • GCC - 699 Dissertation Research  (1 semester hr each Fall and Spring, 2 semester hrs in the summer terms) Although there is a low number of credit hrs, it is considered to be a full time commitment to research.

While registrations appear similar in years 3-5, the nature and character of the research changes and the student passes through a number of steps towards completing their Ph.D.

Integrated Biomedical Sciences: PhD Dissertation Program Progression


Year 1 Classes and Comprehensive Exam:


The goal of the course work in the first year is to expose the student to the biomedical sciences to enable them to design and approach a research problem from molecular, biochemical, cellular and organ system perspectives. The reading courses provide a critical understanding of the literature and existing base of knowledge. They will also show the student how new knowledge in these areas can help us understand diseases and use this information to identify new therapeutics. This broad based approach to disease is the core of the Integrated Biomedical Sciences program. In the Spring Semester, the Topics in Biomedical Integration course (GCC 531 ) is offered. In this course, a specific disease will be studied from the molecular perspective to organ system failure under Faculty direction. The students will them have a group project where they use the approaches they have learned to study another disease. This project will strengthen student skills in preparation of their comprehensive exam. In the summer, GCC 532  Topics in Biomedical Integration II is their comprehensive exam where each student will be given an individualized disease topic related to their planned research. They will be required to write a literature review approaching the topic from each biomedical prospective.

Year 1 Research Experience:


During the first year the student will have three lab rotations. Each rotation must be in a different laboratory. For uncommitted students (funded by the Graduate College or the NIH), the laboratory rotations will expose the student to a range of research environments. Students are expected to learn techniques and attend all lab meetings etc. Based on these rotations, the student will submit the names of three potential advisors with a priority ranking to the IBS education committee. The IBS Education Committee in consultation with the potential advisor will decide which student will be matched with which advisor. Students committed to a particular laboratory, (funded by the research advisor’s grants) are still required to take 3 laboratory rotations. During the first year, the student will select a track and will identify potential research advisors. The Program Director, the track director and the potential research advisors will then select the student’s comprehensive exam topic. Advisors will be identified by the end of Summer term, following the comprehensive exam and completion of rotations

Year 2 Track Selection, Research experience, Qualifying Exam


The selection of Research Advisor will significantly influence the student’s selection of a research track. Subsequent classes will be dictated by the track cognates and electives and by relevant electives offered in other tracks. The selection of electives should complement research activity and the interests of the students and should help prepare him/her for the career choice identified through the use of the Individual Development Plan (IDP) website and additional resources provided by the Graduate College. When the student is not in class or studying, the student should be working on his/her research project. The goals of the 2nd year are to learn the relevant laboratory techniques and to develop a research proposal in conjunction with their research advisor. The research project will advance knowledge in a specific discipline and yield “first author” scientific publications for the student. The student’s research proposal should include at least three Specific Aims and be written up as an F31 grant (See “Dissertation Proposal and Presentation” on the next page). The student must select a Dissertation Committee and present the proposal to the committee by the end of the 2nd year. The proposal presentation to the Committee is considered the Qualifying Exam. Acceptance of the proposal by the Dissertation Committee means the student is a candidate for the PhD. The student’s assessment at this time relates to the following Student outcomes:

  • The graduate is able to acquire research skills, collect and analyze data, and interpret results in order to address an original research question.

In addition, this step begins the continuing assessment of the following outcomes:

  • A graduating student is capable of independent critical thinking and writing as well as proposing, performing and effectively presenting his/her research.
  • The graduate is able to work collaboratively with other scientists, physicians and health care professionals to give and obtain feedback concerning the approach to research problems, data analysis and implications of research.

The student creates an Individual Development Plan (IDP) to better define their areas of interest including teaching, administration, research in industry, or academic research. Upon graduation, the graduate will have used the IDP, mentorship and training opportunities to refine their career path.

Student progress is evaluated at the end of each year, in years 2-5. For Year 2, the student’s mentor and track director will assess student progress relative to expected outcomes. In years 3-5, the student will submit a written report documenting their progress toward expected outcomes. The mentor and track director will also submit their assessment of student progress for the year. Then a meeting with the student, mentor, and track director will take place at the end of each year to discuss the student’s progress.

Year 3-5 Research Progress/Publications/Dissertation


The Research Advisor monitors the day-to-day progress of the student. The Dissertation committee will meet at least once per year to monitor progress and to approve any changes to the proposed research project. They may meet more frequently, especially after the approval of the student’s research proposal. The student is expected to attend national meetings, make presentations, posters etc. and become a part of the scientific community. Likewise, the student should be submitting research articles. The program requires that the research project yield at least one first authored research article accepted for publication in a peer-reviewed journal. The publication requirement is necessary for graduation but not sufficient. The Dissertation Committee will continue to assess student progress on the aims and determines when the student has completed his/her dissertation. (See Dissertation Proposal and Presentation below)

The student’s assessment continues on the outcomes listed above with emphasis on the growth of research and communication skills. Likewise it is expected that the communication outcomes will also become more centered on written communication in the form of abstracts, peer reviewed journal articles and dissertation as the student begins to complete the following outcome: The graduate is able to contribute to the scientific literature in an area of expertise via published abstracts, a dissertation and by the publication of a first authored research article in a refereed journal.

Minimal Credit Hours Required for the Integrated Biomedical Sciences PhD Degree


The PhD in Integrated Biomedical Sciences should be completed in five years and requires completion of 145 semester hours of credit distributed as follows: core courses (37), concentration specific cognates (16), electives (9), and dissertation research (83). The core curriculum, which will be common to all students, builds knowledge and skills in research theories and methodology, data analysis and statistics, laboratory applications and skills, and the molecular and cellular sciences basic to health and disease. These courses will provide systematic exposure to the contemporary process of scientific discovery and will serve as the basis for the remainder of the curriculum. Advanced students entering with a master’s (MS) degree in a biomedical science or a doctor of medicine (MD) degree may have classes in the first two years waived based on their prior record. The degree may then be completed in a shorter time providing the student progresses through the process outlined below. Students will be required, in conjunction with their advisors, to select from concentration focused cognates in one of five tracks: Translational Cancer Research; Cardiovascular and Respiratory Biology; Immunity, Inflammation, and Infection; Disorders of the Musculoskeletal System; and Disorders of the Nervous System. All students will be required to participate in track specific Advanced Topic Seminars that span terms 4 through 15. All students will also be required to complete a minimum of 83 SH dedicated to completion of their dissertation research. Dissertation hours are consistent across all Natural Science PhD programs in the Graduate College and encompass laboratory research time required for completion of the dissertation including: analyzing published data; developing a research proposal; learning and applying advanced methodologies and statistical data analyses; developing skills to write and submit a pre-doctoral training grant application; practicing presentation skills to disseminate own research findings in national conferences; writing in the form of a research publication, and developing and defending a dissertation project

Integrated Biomedical Sciences: Academic Policies


Academic Advisor/Principal Advisor


The IBS Program Director functions as the academic advisor to the students during the first year of matriculation in the program. At the end of the first year, the student will identify the track that they wish to enter and will begin working in the laboratory of his/her Research Advisor. At this time, the Track director along with the Research Advisor will serve as mentors for the student.

Research Advisor selection:


During the first year the student in consultation with the Program Director and Track Directors in areas related to the student’s interests will select 3 laboratories for research rotations. Based on these rotations, the student will identify the track they are interested in and submit the names of three potential advisors with a priority ranking to the IBS education committee. The IBS Education Committee in consultation with the potential advisor will decide which students will be matched with which advisors. Students who upon entering the program are committed to a particular laboratory (funded by the research advisor’s grants) are still required to take 3 laboratory rotations. The student’s research project should advance knowledge in a specific discipline and yield “first-author” scientific publications for the student.

Integrated Biomedical Sciences: Track/ Research Opportunities


The research Tracks for the Integrated Biomedical Sciences PhD Program are: Translational Cancer Research; Cardiovascular and Respiratory Biology; Immunity, Inflammation, and Infection; Functions and Disorders of the Musculoskeletal System; and Functions and Disorders of the Nervous System. The tracks include qualified faculty from Rush University Medical Center who have an interest in research in these tracks. They come from academic departments as well as clinical departments, which enables the student to select a variety of individuals with basic and clinical expertise to serve on their advisory committee and guide them through their project.

Qualifying Exams


  • Comprehensive exam - In the summer quarter following the first year of classes, all students will take GCC 532 ; Topics in Biomedical Integration II. This course is their comprehensive exam where each student will be given an individualized disease topic related to their planned research. They will be required to write a literature review approaching the topic. This comprehensive exam assures that the student can approach a research or clinical problem from a variety of perspectives, accounting for the published literature that illuminates the molecular, cellular and organ systems manifestations of the disease process.
  • Qualifying Exam (Dissertation Proposal and Presentation) - The student must select a Dissertation Committee and present the proposal to the committee by the end of the 2nd year. The student’s research proposal should include at least three Specific Aims and be written up as an F31 grant. Acceptance of the proposal by the Dissertation Committee means the student is a candidate for the PhD.

Dissertation Research Committee


After passing comprehensive exams, the student will select a research advisor and begins to collect preliminary data. By the end of Spring of the 2nd year the student and advisor will select a research committee in consultation with the Track Director. This committee will advise the student and evaluate their dissertation. The Graduate College requires that the committee includes 5 members and that one member must be the student’s mentor/advisor. A majority of the Committee (at least three members) must be faculty at Rush who are members of The Graduate College. The chair of this committee, who cannot be the student’s mentor/advisor, will be chosen at the first committee meeting and will preside at all subsequent meetings and arrange for a timely completion of the dissertation work. The dissertation committee will strive for consensus in all its actions, however, a majority vote of the committee’s membership, is sufficient for all activities except the final approval of the dissertation, only one member may disagree with the final decision. In addition to the five-committee members, either the Director of the Graduate Program, the Associate Director or a Track Director will serve as an ex officio member of the committee.

Dissertation Proposal and Presentation


All students will present a thesis proposal before the end of the Spring Semester of their 2nd year that they have developed with their thesis advisor and graduate committee. The format for the written portion of this requirement is the standard Individual National Research Service Award (F31) mechanism. In addition, a comprehensive review of the literature relevant to the proposed studies is highly recommended as an adjunct document for this requirement. [All students are highly encouraged to submit these proposals to the National Institutes of Health for consideration of funding. The schedule for submission deadlines is April 8th, August 8th, and December 8th of every year]. Once the written document is completed, the thesis proposal will be presented in a seminar format to the Integrated Biomedical Sciences program with the written portion provided to the student’s committee at least 1 week prior to the presentation date. A formal committee meeting with thesis proposal defense will follow this presentation. During this meeting, the quality and merit of the project will be made and a determination as to whether the work satisfies the degree requirements or what measures for remediation are required to satisfy this requirement will be made at this time. Upon successful completion of this requirement the status of doctoral candidate is conferred on to the student. It is recommended this requirement be satisfied as early in the 2nd year as reasonably attainable. In the event student’s do not satisfy this requirement before the termination of the Fall semester of the 3rd year, the student and their advisor will need to present to the IBS Education Committee a reason as to why this requirement has not been satisfied and provide a plan for remediation.

Once the dissertation proposal requirement has been satisfied, all students will present an annual update to their committee in an identical format as the original proposal meeting with exception to the anticipated year for graduation. Again, after the seminar, a meeting between each doctoral candidate with their committee will occur and progress in the last year for their project and in their career development will reviewed. A detailed written account for each area should be distributed to the committee prior to this meeting. In addition to this, the web site that helps students identify career goals, my Individual Development Plan (myIDP) should be used whenever possible to track and report all professional development activities.

Completion of the Degree


In the candidate’s final year, a Thesis Data Defense will be presented to their thesis committee demonstrating that satisfactory progress have been made on the project to justify development of a plan to complete all experiments and to initiate dissertation preparation. Upon completion of this phase, the student will present the dissertation to the University in written form (approved by the Director of the Library of Rush University Medical Center) and present the work in a public one-hour lecture attended by the dissertation committee and faculty and students of the University. The dissertation committee will then meet in closed session with additional questions and will approve the dissertation. Typically the meeting immediately follows the public lecture. In line with the rules and procedures of The Graduate College, the committee strives for a consensus, but the dissertation can be approved over the objections of a single committee member. However, if two committee members disapprove the dissertation, then it is not approved. The awarding of the PhD degree requires the demonstration of a capability for independent research and a contribution to scientific knowledge.

It is assumed that one or more research articles are included in the dissertation. Since a peer reviewed first authored research article is required for the degree, the dissertation is not considered complete until its publication. If publication is pending, the committee may sign off on the dissertation but the program director will not sign off until the paper is published.

The Registrars office must be notified of impending completion of the degree by submission of an “intent to graduate” form at the beginning of the final semester. As the Dissertation is reaching final form, the student should consult with the University Librarian to assure that the Dissertation is formatted correctly. Once the dissertation is approved, the student will complete the final checklist to assure that all necessary approvals have been obtained. Students will be required to have an exit interview and provide feedback concerning their experience at Rush University.

Student Grievance Procedure


A student, who is having difficulty with a course and anticipates being absent from class or faces an emergency that will impact their attendance or performance, should contact their course director. A student with a problem in their laboratory rotations or research should attempt to resolve the issue through direct communication with the laboratory advisor or mentor. A good faith attempt to plan/resolve any issues directly with the course director, laboratory advisor or mentor should always be the first course of action. If this fails, the student should bring their concern to the program director if they are a first year student or to their track director if they have already identified a track. The program director or track director will work with the student and faculty member(s) to resolve the issue. If it is a serious issue, the program director, track director or faculty member may involve the Education Committee. The student may also appeal directly to the Education Committee by requesting in writing that it meet to discuss the issue. The Education Committee will meet within 10 days to render a judgment to best address the interests of the student within the guidelines of the Integrated Biomedical Sciences PhD program.

Students must maintain a B average in the first year. If they drop below a B average, they should discuss the possibility of remediation with the director of the course they had difficulty with. The course director may issue an incomplete grade for a limited time in accordance with university policy while agreed upon remediation takes place. However, once a failing grade (no Pass or letter grade less than B) has been given, the Education Committee must approve a remediation plan. Until a grade is remedied or his/her average is improved in some other way, the student is on probation. A student who remains on probation for two semesters will be dismissed.

Students who have entered a track must receive at least a B grade in any courses deemed required by their tract director. Failure to remediate a grade of less than B in a required course or a no-pass grade in a pass/no-pass course or the receipt of another such grade while on probation will result in dismissal.

The Education Committee will also hear complaints concerning academic dishonesty, non-professional behavior and student misconduct. The council may become involved through a direct request from a student or faculty member or by a referral from the Honor Code Committee. If the Honor Code Committee has not been involved, the council may refer the initial request to the Honor Code Committee. The council will hear testimony from any involved faculty and/or students. The council may recommend remediation or disciplinary measures. Recommendations for expulsion or suspension are made to the office Dean of the Graduate College. Appeals will be heard by the Graduate College Council (GCC) or a subcommittee of the GCC that will be organized solely for the purpose of hearing the appeal and making a recommendation to the Dean. The ultimate decision regarding student expulsion or suspension rests in the office of the Dean of the Graduate College.

Graduate College/Rush University Academic Policies


Integrated Biomedical Sciences: PhD Tuition Scholarship and Stipend


All students who are admitted to the IBS PhD program at Rush University Medical Center will receive a tuition waver and stipend. The stipend is awarded annually and renewed if the student remains in good standing. To remain in good standing, the Graduate College requires that students maintain at least a “B” average failure to do so will result in the student being on probation, if the student does not have a B average following one semester of probation, they may loose their stipend. Students are expected to attend all classes and spend the appropriate time in the lab. All outside employment is forbidden without prior graduate college approval as it interferes with the time and effort necessary to complete the program. This excludes activities that would be in line with Individual Development Plan goals like tutoring, teaching and proctoring.